Category: Ponce Research Institute

  • Get to Know our Ponce-RCMI Team! – Dr. Richard Noel

    Get to Know our Ponce-RCMI Team! – Dr. Richard Noel

    Dr. Richard Noel is a PHSU investigator from our Ponce Research Institute as part of the Ponce-RCMI Project. He has a partnership role as a PI. Currently responsible for the investigator’s development and the coordination of three major projects: The Research Core, Community Core and the investigators development core.

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    His contributions are supporting the ongoing projects to facilitate its progress, organizing a call for applications of the internal pilot project funding, and opening the training program of the investigator development core. But not only does he contribute at a local level, but he is also engaged at the national level where he serves on the organizing committee for the RCMI 2019 National Conference where he is the Chair of the abstract committee for that meeting to be taken place on December 15-19 in Maryland.

    As part such an important project Dr. Noel wishes to share with the community that for 34 years, the RCMI program at PHSU is the primary support for biomedical research infrastructure and provides significant funding to individual research projects. The program is responsible for the recruiting of research faculty for the past 30 years and in the next five years is projected to support the addition of 10 new research faculty to PHSU. The RCMI Project sponsor’s a training and career development program for faculty in all PHSU schools and programs and provides research development support for short term projects and projects spanning up to two years.

    Also, the RCMI program started a community investigator training program that will promote collaboration of institutional scientists and community leaders to address important areas of health disparity – a first of its kind at PHSU and novel in Puerto Rico for the scope and depth of training that will be available to four cohorts of community leaders. Each of these activities, as well as three major scientific projects, a clinical study of perinatal outcomes for children exposed to ZIKA, a behavioral study of early-life stress related to cancer progression, and a basic science study of developmental stress and addiction effects on adult post-trauma stress, all offer different avenues to get involved.

    “There is no substitute for gaining research experience; it is never too late (even final year in college) nor too early (we have outreach to grade school children and each summer host high school students in our labs) to do so. Also, you need to be a serious student – you need strong grades in challenging classes and you need to learn from those classes (not just get good grades)”

     

     

     

  • Get to know our RCMI Team! – Doris Andujar

    Get to know our RCMI Team! – Doris Andujar

    Doris Andujar

    All Scientific projects are conducted by a team’s effort. If your interest relies on regulations and compliances and science, you should get to know Ms. Doris Andujar, MPH.  She is the Program Executive Manager responsible for providing administration support to the Principal Investigators (Dr. José Torres and Dr. Richard Noel) in all activities conducted through the RCMI Program at PHSU.

    Ms. Andujar ensures federal grant compliance with all applicable state and federal laws, rules, and regulations. Assist the principal investigators and core/project leaders with proposal development, grants management (pre-award and post-award), budget management and forecasting, data management, monitoring and evaluation, resolution of accounting problems/errors; and functioning as liaison to federal and non-federal granter agencies and subcontracting institutions. She is also in charge of assisting the PI’s in the development and implementation of collaborative agreements/partnerships with other research-intensive institutions.

    Among the important aspects to share with the community upon the RCMI Program; MS. Andujar tells us that NIH funded 11 Research Centers in Minority Institutions Specialized Centers nationally and PHSU – Ponce Research Institute is one of the privileged awardees.

    She quotes: “Historically, this funding opportunity is designed to develop and strengthen the research infrastructure necessary to conduct state-of-the-art biomedical research and foster the next generation of researchers from underrepresented populations.  The overall goals are to advance the science of minority health and health disparities in multiple disciplines, promote the diversity of the biomedical workforce and reduce health disparities and promote health equity. (NIH News Release 8/23/19; link: https://www.nih.gov/news-events/news-releases/nih-funds-eleven-research-centers-minority-institutions)”.

    As the Program Executive Manager, she states that it’s important for everyone to get to know how the RCMI Program, titled PHSU Specialized Center in Health is the biggest federal grant with a history of over 30 years on PHSU main campus, which she believes to be one of a kind. Also highlights how it’s important for everyone to get to know the contributions upon the RCMI Programs Cores. For example, the laboratory cores AIDS, BRAIN, and MAGIC merged and enhanced to become the Center for Research Resources open to faculty, students, collaborators, and clients at the local, national, and international levels.

    She also addresses that the Community Engagement Core founded with the Community-Based Participatory Research model, trains community members, living in Southern Puerto Rico, on research and health education, in addition to providing support to our faculty researchers. And last but not least, the Investigator Development Core known as START (Strategic Academic Research Training Core) established a two-year career development curriculum for post-docs and junior research faculty and funds peer-reviewed pilot projects. These cores support the three full research projects on basic biomedical, behavioral, and clinical research.

    It is evident that Ms. Andujar represents a great professional and asset for the RCMI Program. We recognize her commitment and quote her best wishes to future students that want to become future researchers:

     “Students, you are the authors of a new chapter in your book of life once you decide to get a graduate degree. Each year at PHSU is not just another year at a new university; it is a new year full of expectations and opportunities you might have never imagined. Research is one of those opportunities that PHSU offers. To excel as a health professional and spearhead a topic of interest in research, you must be disciplined, respectful, perseverant and tenacious, a good citizen, responsible, just, honest, curious, open-minded, committed, and have integrity.  Todd Pettigrew, an English Professor at Cape Breton University, adds to these characteristics ambition, humility, and creativity (when he thinks about his best students).

    Above all these qualities, for me, the most important is PASSION. Sister Isolina Ferré refers to passion as the inner tickle that leads you to do things regardless of receiving anything in change, just the satisfaction of having had an impact on the life of those that surround you. Passion is what will lead you to achieve your purpose, your goals, starting with learning health competencies, research methods, meeting graduation requirements, and then applying all the knowledge and skills in a research career. If we apply this concept to health sciences overall, it would be to lead us through passion achieving a translational impact from the lab to the bedside and even more important at the population level.

    As a colleague, I urge you to be bold. Dare to Be Different, think out of the box and go beyond your limits. It is ok to be afraid, but do not feel powerless. Dare to believe in yourself, in your talents, in your abilities, in your potential to be an excellent student and professional. Dare to have enthusiasm for your education and research, to learn every day, because you never stop learning. Dare to use all the resources offered by the university (including professors and academic counselors)Dare to ask for help, but also dare to help those who need it and teach them your knowledge because you did select a career that builds on teamwork.

    Dare to take opportunities for work-study, employment, to volunteer in the various projects and committees in the institution (this is how I started at PHSU, as a volunteer, and today I am the Program Executive Manager of RCMI and Assistant Director of the Office of Research Development). Take a look into Ponce Research Institute and explore what investigations are underway and see how you can be of help. Become a research assistant, present studies at local, national, and international levels. Expose yourself, network, and let people know who you are and what you can do. Also, take-action and develop community initiative activities with your professors and colleagues. Engage community members in your research studies so they can be your advocates locally.

    In summary, you have come this far to be a valuable resource that society needs. Don’t give up, fight, and conquer your goals with great fervor. I wish you all great success!!

    “Always listen to experts. They’ll tell you what can’t be done, and why. Then do it!”

    ~Robert A. Heinlein”

     

     

     

  • Subvención de 22 millones de dólares permitirá desarrollar  Centro Especializado en Disparidades de Salud

    Subvención de 22 millones de dólares permitirá desarrollar Centro Especializado en Disparidades de Salud

    La ayuda también dará continuidad al Programa de Research Centers in Minority Institutions (RCMI)

     

    El Instituto de Salud de Minorías y Disparidades de Salud (NIMHD) de los Institutos Nacionales de Salud (NIH) anunciaron la renovación del Programa Research Centers in Minority Institutions (RCMI) en Ponce Health Sciences University (PHSU). Esto mediante la otorgación de una subvención de 22 millones de dólares por cinco años adicionales.

    Durante los pasados 33 años, el financiamiento a través del Programa de RCMI en PHSU ha sido fundamental en el establecimiento y desarrollo de una infraestructura de avanzada para proseguir investigación científica en las áreas básicas, clínicas y en las ciencias del comportamiento humano.  El RCMI ha sido una pieza clave en la transformación de PHSU de una institución esencialmente de enseñanza graduada, a un centro vigoroso de investigación científica. La contribución del Programa ha ayudado a la facultad de PHSU en aumentar el número y la calidad de publicaciones en revistas científicas indexadas de alto prestigio y presentaciones en foros de alta visibilidad tanto a nivel local, nacional, e internacional. Esto, a su vez, ha repercutido en posicionar a la institución a un nivel de competitividad que le ha permitido recibir múltiples subvenciones para investigación y adiestramiento de nuevos científicos biomédicos.

    Lideres del Programa RCMI en Ponce Research Institute (PRI)

    “Nos sentimos sumamente honrados en que nuestro Programa de RCMI haya sido renovado. Ciertamente, en un panorama actual de tanta competitividad para recibir fondos federales dirigidos a la investigación científica, este éxito constituye una clara evidencia del compromiso incondicional de nuestra facultad y de la calidad del trabajo que ellos realizan día a día. La renovación del Programa nos permitirá establecer un Centro Especializado en Disparidades de Salud en la zona sur de Puerto Rico. Este Centro tiene como propósito principal el promover investigación traslacional (la que lleva los resultados de investigación directamente a la atención médico/paciente) de calidad con un énfasis particular en el área de disparidades de salud a nivel local e internacional”, expresó el Dr. Jose A. Torres-Ruiz, Rector de PHSU e Investigador Principal del Programa.

    El Dr. Richard Noel, coinvestigador principal del Programa RCMI expresó que, “Este apoyo financiero es instrumental en nuestros esfuerzos de continuarinvestigando sobre enfermedades que afectan la población de Puerto Rico de forma desproporcionada. Mantener una infraestructura de vanguardia y el fortalecer alianzas con la comunidad son estrategias claves que se impulsarán desde el Centro”.

    La propuesta desarrollada del Centro Especializado en Disparidades de Salud “es uno muy relevante a Puerto Rico”, expresó el Dr. Torres-Ruíz, quien explicó que el término “disparidades de salud” es utilizado para referirse a cualquier diferencia prevenible en la salud en poblaciones vulnerables en cuanto a la distribución de ciertas enfermedades, causas de muerte, factores de riesgo, y otros aspectos relacionados a la salud. “Debido a que somos una población predominantemente hispana que reside en una isla, tenemos una mayor carga de algunas condiciones como el cáncer, la diabetes, condiciones neurológicas, entre otras”, expresó el Dr. Torres-Ruíz.

    Por su parte la Dra. Kenira Thompson, presidenta de Ponce Research Institute y vice presidenta de investigación en PHSU mencionó que, “Nos sentimos muy orgullosos de nuestro equipo de investigadores que se han unido para conceptualizar e implantar el Centro Especializado en Disparidades de Salud en PHSU. Con este auspicio financiero, continuaremos con nuestrocompromiso incondicional de trabajar firmemente en resolver los retos más apremiantes que impactan la salud de la comunidad hispana”.

    Sobre el Centro Especializado en Disparidades de Salud

    El Centro Especializado en Disparidades de Salud integrará el peritaje y experiencia de más de 15 facultativos asociados a los diferentes programas académicos de PHSU, además de un número significativo de estudiantes graduados y de personal de apoyo.  Este grupo de profesionales contribuirá al mandato nacional de establecer estrategias para prevenir o reducir las incidencias de disparidades en la salud de la sociedad, y de forma muy particular en comunidades desventajadas.

     

    Este Centro propone ofrecer una variedad de servicios y actividades científicas incluyendo el establecimiento de modernas instalaciones físicas y tecnologías impactando la evolución de los proyectos científicos. La implementación de estrategias novedosas va dirigida a cultivar la facultad joven y convertirlos en investigadores altamente competentes para aumentar y mejorar la fuerza laboral en las áreas de prioridad del Centro. Esta infraestructura innovadora del Centro permite promover estudios competitivos que toman en consideración los sectores más vulnerables de la comunidad en relación con el tema de las disparidades de salud que presentan.

    El Centro, además, apoyará la implantación de tres proyectos científicos de alto calibre que han sido diseñados para entender de forma más amplia las problemáticas en disparidades de salud en la adicción de sustancias, el efecto de estrés en la proliferación del cáncer, y sobre las consecuencias neurológicas de pacientes pediátricos que fueron expuestos a la infección de ZIKA durante el embarazo. Los resultados que emanen de estos estudios auspiciados por el Centro Especializado de Disparidades de Salud propiciarán información clave para comprender y responder de manera más contundente a los factores que contribuyen a las disparidades en la salud que afectan predominantemente la comunidad puertorriqueña.

    Doris Andújar, Administradora del Proyecto RCMI, Kenira Thompson, Presidenta de PRI, Dr. José A. Torres-Ruiz, Rector de PHSU e Investigador Principal del Proyecto RCMI, Dr. Richard Noel, Investigador Principal del Proyecto RCMI

    Se informó que este centro será administrado por el Dr. Jose A. Torres Ruiz, rector de la institución, y por el Dr. Richard Noel, director del Departamento de Ciencias Básicas de PHSU. Los doctores Torres Ruiz y Noel fungirán como investigador principal de contacto y coinvestigador principal, respectivamente.

     

    Para más información sobre el programa RCMI y el propuesto Centro de Disparidades de Salud las personas interesadas pueden escribir a: jtorres@psm.edu,

    rnoel@psm.edu o dandujar@psm.edu. También pueden llamar al 787-840-2575 ext. 2283.

     

     

     

     

     

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  • NIH awarded Ponce Health Science University $4.4M to renovate the Ponce Research Institute facilities.

    NIH awarded Ponce Health Science University $4.4M to renovate the Ponce Research Institute facilities.

     

    Today we reflect on the past two years as it is the Anniversary of Hurricane María. During the day, please take some time to remember, as well as how we came together as a community to help rebuild our campus and southcentral Puerto Rico, as well as honor the memory of all of those who lost their lives in the aftermath.

     As part of our ongoing work to establish a more robust research enterprise, I am proud and excited to announce that the NIH has awarded PRI $4.4M to restore our main Research Building (Building F).  This is a wonderful testament to the hard work, dedication, and perseverance of our team!!  This grant was submitted during the Christmas break in 2018, and required high-level coordination with multiple stakeholders with a very tight deadline/timeline.  The grant will allow for an interior remodel of our research labs, as well as the implementation of full off-the grid solar power, and fixed storm window shutters in order to maximize the resiliency of our facility. 

     We have a two-year timeline for this renovation, so the Project Management Team will soon be contacting all researchers that may be impacted by the project, in order to coordinate activities to maximize productivity as well as mitigate potential interruptions to research activities.  We look forward to working with all of you as we proceed with this much-awaited and needed facelift to our research building.

    Thanks for your continued efforts towards the growth and expansion of research at our institution. I am proud of what you do!

     

    Kenira Thompson, Ph.D.
    Vice President for Research
    Ponce Health Sciences University
    President, Ponce Research Institute

     

  • PHSU receives $398,854 grant to research cancer screening practices among Latin transgenders

    PHSU receives $398,854 grant to research cancer screening practices among Latin transgenders

     

    The National Cancer Institute presented this significant funding to the Ponce Health Sciences University

     

    The U.S. National Cancer Institute granted $398,854 to the Ponce Health Sciences University (PHSU), to conduct a study with the goal of understanding the obstacles associated with cancer screening among Latin transgender individuals in Puerto Rico and Florida. The study, set to last two years, will be the first of its kind in Latin populations and is a collaboration between PHSU’s School of Behavioral and Brain Sciences, Florida International University’s Steven J. Green of International and Public Affairs, and The Center for AIDS Prevention Studies at the University of California, in San Francisco.

    “Thanks to this contribution, and through this study, we will be able to document the obstacles for cervical and breast cancer screening among the Latin transgender population in Puerto Rico and Florida. These data will allow us to develop strategies to promote cervical and breast cancer prevention within this population,” said Dr. Alíxida G. Ramos-Pibernus, director of the Clinical Psychology’s PhD program at PHSU. Ramos-Pibernus also said that this study pushes forward the agenda to reduce the health disparities that the transgender community experiences.

    Researchers will interview and survey Latin transgender individuals to document the obstacles associated to cancer screening. The data obtained will inform the development of interventions to reduce and overcome the obstacles identified. The research team is comprised of doctors Alíxida Ramos-Pibernus (Main Researcher; SBBS-PHSU), Sheilla L. Rodríguez-Madera (Main Researcher; SIPA-FIU); Eida Castro (Co-researcher; PHSU) Nelson Varas-Díaz (Co-researcher; SIPA-FIU), Torsten Neilands (Co-researcher; CAPS- UCSF), y Eliut Rivera-Segarra (Project Director, SBBS-PHSU).

     

    According to Ramos-Pibernus, more than 1.7 million new cancer cases are diagnosed in the U.S. and its territories, 37% of which are breast and cervical cancers. Also, cancer is one of the main causes of death among Latins in this context. “In fact, in Puerto Rico and Florida, 18% and 22% of all deaths, respectively, are caused by this condition. Cancer screening is one of the most important behaviors to prevent the condition,” said Ramos-Pibernus.

    The U.S. Centers for Disease Control and Prevention has identified that the LGBTT community is disproportionately impacted by cancer, and that transgender individuals within the community face notable disparities associated to this disease. Unfortunately, very little is known about the obstacles transgenders face to get cancer screening.

    For more information, please contact the study’s main researchers, doctors Alíxida Ramos-Pibernus and Sheilla L. Rodríguez-Madera, via email, at either aliramos@psm.edu or shrodrig@fiu.edu.

    Ponce Health Sciences University is an academic institution focused on the disciplines of Medicine, Clinical Psychology, Biomedical Sciences, Public Health, and Nursing. Since 1977, it has developed highly capable professionals in the field of health care. Its newest academic center, in Santurce, offers a master’s program in Medical Sciences and a doctorate in Clinical Psychology.

    To learn more about Ponce Health Sciences University, please call 787-840-2575, ext. 5724, or visit www.psm.edu.

     

  • Fortaleciendo el aprendizaje: importante concepto para ayudar a nuestros hijos en el retorno a la escuela

    Fortaleciendo el aprendizaje: importante concepto para ayudar a nuestros hijos en el retorno a la escuela

    Ya casi termina el verano y todos comienzan a pensar en el “back to school”.  En un abrir y cerrar de ojos dejamos atrás los campamentos, los días de playa y los pensamientos giran en torno a los materiales escolares, la venta sin IVU, los uniformes, el comenzar a madrugar a los nenes otra vez, los tapones, y sí, nos guste o no, las asignaciones que se avecinan.

    Todos tenemos la esperanza de que el nuevo año académico sea exitoso (hasta el “teen” que nunca lo admitiría).  Los diferentes estilos de aprendizaje juegan un papel importante en ese éxito, pero quizás no de la manera que tradicionalmente lo pensamos.

    Interesantemente, algunas de las creencias populares sobre el aprendizaje están un poco desacertadas.  Muchas veces te habrás preguntado qué tipo de “aprendiz” eres…auditivo, visual o sensorial/físico.  Es cierto que los estudiantes muchas veces tienen mayor fortaleza en un área versus otra. Sin embargo, a pesar de muchos intentos de parear métodos de enseñanza con estilos de aprendizaje, no todos han sido exitosos.  Desde un punto de vista práctico, probablemente no sea posible crear una tarea escolar puramente auditiva, visual, o sensorial.  Además, el enseñar solamente usando las fortalezas del estudiante pudiera ponerlos en desventaja en el mundo real, al permitir que las debilidades (o áreas menos fuertes) permanezcan, o aún peor, se intensifiquen.

    Desde un punto de vista biológico, el cerebro no funciona así.  Nuestros sistemas auditivos, visuales y sensoriales no operan en aislamiento.  Al contrario, nuestro cerebro está constantemente integrando información de múltiples fuentes.  De hecho, la mayoría de los estudiantes aprenden más efectivamente con enseñanza multi-modal, donde se utiliza más de un método para poder procesar, entender y recordar nueva información.

    Ayuda a tu hijo a reconocer sus fortalezas, para que le sirvan para vencer (o minimizar) sus debilidades.  Si le gustan más las palabras que las matemáticas, vamos a ayudarle a aprender a verbalizar—o hablar para resolver los ejercicios matemáticos.

    Durante este próximo año académico, vamos a animarlos a usar destrezas de estudio multi-modales.  Que al estudiar incorporen varios métodos, desde el tomar notas, repetir en voz alta la información, dibujar diagramas para entender conceptos, incluir la tecnología (computadora para ver videos sobre el tema), hasta el usar rimas y canciones para memorizar información importante.

    Las creencias u opiniones que un estudiante tiene sobre sus capacidades o destrezas juegan un papel importante en su auto-confianza académica.  Aquellos que adoptan una mentalidad de “crecimiento dinámico” (growth mindset), al entender que sus habilidades son cualidades que pueden desarrollar y fortalecer, tienden a demostrar mayor motivación que aquellos que adoptan una mentalidad de que sus habilidades son lo que son y que no se pueden cambiar (fixed mindset). Mientras es natural que validemos las capacidades innatas de nuestros niños, diciéndole que son “listos e inteligentes”, debemos recordar que el enfocarnos demasiado en esas capacidades innatas promueve el que perdure la mentalidad de que las capacidades son lo que son y no se pueden alterar.

    Aquellos niños que creen que son exitosos solamente por su inteligencia innata pueden percibir tareas difíciles como una señal de debilidad, lo cual los lleva a evitar dichas tareas.  Es mejor que los ayudemos a enfocarse en la conexión que existe entre esfuerzo y aprendizaje, ya que así aprenderán lo que se necesita para triunfar. Esto les da un sentido de empoderamiento y les permite enfrentar tareas difíciles como oportunidades de aprender algo nuevo.

    Felicita a tu hijo por sus esfuerzos, no solamente por sus habilidades.  Resalta los momentos en que sus esfuerzos dieron fruto.

    Apóyalos a enfrentar los retos.  Enséñale que, si una tarea es difícil, no es porque no sean inteligentes, es porque es quizás es un tema nuevo, diferente, algo a lo que hay que dedicarle un poco más de tiempo y esfuerzo.

    Sirve de modelo para que amen el aprendizaje. Incorpora el aprender en tareas cotidianas del hogar, como el cocinar, ir al supermercado…hasta en el tapón de camino a la escuela se puede aprender.

    Recuerda que las tareas de tus hijos van más allá de la lectura, la matemática y la ciencia.  El ayudarles a mejorar su autoestima académica y estimularlos a aceptar los retos del nuevo año escolar será la receta para ir forjando en ellos un amor por el aprendizaje que perdure para siempre.

     

                                           

    Autora: Kenira J. Thompson, Ph.D.

    Profesora de Neurociencia

    Vice Presidenta de Investigación, Ponce Health Sciences University

    Presidenta de Ponce Research Institute

  • New Clinical Research Office opens at Ponce Research Institute

    New Clinical Research Office opens at Ponce Research Institute

    New Clinical Research Office opens at Ponce Research Institute

    Will collaborate with the Moffitt Cancer Center in Florida

    Ponce Health Sciences University (PHSU) announced the inauguration of a new Clinical Research Office as part of the Ponce Research Institute. The purpose of this new office is to strengthen clinical research taking place at PHSU. It will provide infrastructure within the university to develop and coordinate studies, quality service, and mentoring to help new and established researchers in all phases of their work. The opening of this office begins with a collaboration with the Moffitt Cancer Center in Florida that will allow for the creation of a network of clinical trials in Puerto Rico.

    “Our vision is to reduce the disparities in clinical research and oncology treatment in Puerto Rico by increasing the capacity for clinical research while providing unique research experiences to researchers, patients, and sponsors. The Clinical Research Office will also provide scientific support to the Ponce Research Institute which investigates new therapies and options in the area of disease prevention,” said Dr. Roberto Torres, director of the Clinical Research Office.

    Speaking about the clinical trials, Dr. Torres added that these “may provide access to new treatments, while patients receive close oversight, counseling, attention, and support from the research team. Also, they allow patients to understand better their illness or condition, and the opportunity to be part of discoveries that benefit society,” he said.

    Ponce Health Sciences University is an institution focused on medicine, clinical psychology, biomedical sciences, public health, and nursing. Since 1977 it has developed highly capable professionals in the field of health. It now has an educational center in Santurce that offers a master’s in medical sciences and a doctorate in clinical psychology.

    To learn more about Ponce Health Sciences University, contact 787-840-2575, ext. 5724 or visit www.psm.edu.

    About Ponce Research Institute

    Ponce Research Institute is part of Ponce Medical School Foundation, Inc., a non-profit entity (501 c.3) that provides the research infrastructure to Ponce Health Sciences University. Its mission is to conduct high-quality research that help to decrease the health disparities faced by Puerto Rican patients.

    About Moffitt Cancer Center

    The Clinical Research Office of the Ponce Research Institute and The Moffitt Cancer Center Association were created to overcome the disparities in clinical research and oncology treatments among the Hispanic/Latino population, evidenced by diagnosis in advanced stages, barriers for patient care, as well as the lack of representation in clinical trials about cancer.

  • When breast cancer runs in the family

    Julie Dutil, Ph.D.

    Associate Professor of Basic Sciences

    Cancer Biology Research Division

    Ponce Health Sciences University

    Ponce Research Institute

    Many of us know a relative or a close friend that has been diagnosed with a cancer. This is not surprising as cancers are common. It is estimated that around one in eight women will develop breast cancer in her lifetime. Most breast cancers are caused by a combination of risk factors including age, body weight, hormonal exposure, reproductive and lifestyle factors. A small percentage of all breast cancers cluster in families and are thought to be hereditary, caused by abnormal genes passed from parent to child.

    Our genes contain the instructions for building proteins, which are controlling the structure and functions of our cells. We inherit two copies of each of our 21,000 genes, one from our mother and the other from the father. There are millions of variations in genes, which is the reason why no two persons are the same. While most of those changes are harmless, some are errors or mistakes, which can impede the function of a gene. Those changes are known as mutations.

    The majority of inherited cases of breast cancer are associated with mutations in two genes: BRCA1 and BRCA2. Everyone has BRCA1 and BRCA2 genes, and their normal function in DNA repair is essential for cells to grow normally. When a person inherits a defective BRCA1 or BRCA2 gene from the mother or the father, it results in increased risk of breast, ovarian or other cancers. Having a BRCA1 or BRCA2 mutation doesn’t mean you will be diagnosed with breast cancer, but your chances are much higher. For example, women who have a BRCA1 mutation or BRCA2 mutation can have up to an 80% risk of being diagnosed with breast cancer during their lifetimes. Today, we know more than 50 genes that are involved in determining cancer risk, each associated with different risk of cancers. In many families, the genetic changes associated with hereditary breast cancer are unknown. Identifying additional genetic risk factors for breast cancer is an active area of medical research.

    In order to determine if you and your family are carrier of a hereditary cancer mutation, a genetic test must be performed from a blood or saliva sample. Not everyone should be tested for hereditary cancer genes. If you or some of your close relatives have had breast or ovarian cancer, especially at young ages, in both breast, or a particular type of breast cancer known as triple-negative, or if there are other cancers in your family in addition to breast, such as prostate, melanoma, pancreatic, stomach, uterine, thyroid, colon, and/or sarcoma, you may consider hereditary cancer testing.

    Although it can cause anxiety to find out that you have a genetic predisposition to cancers, knowing about your genes can also empower you to take preventive actions, make positive changes to your lifestyle and keep an eye on certain cancers for which you are at higher risk through regular screening. It is also a process that involves the entire family. Before undergoing genetic testing, make sure you understand the risks, benefits and limitations by talking to your healthcare provider.

    Ponce Health Sciences University, before known as Ponce School of Medicine, is an institution focused on the disciplines of Medicine, Clinical Psychology, Biomedical Sciences, Public Health and Nursing. Since 1977 has developed highly trained professionals in health field. Now it has a university center in San Juan that offers a Masters in Medical Sciences and a Doctorate in Clinical Psychology.

     

    To learn more about Ponce Health Sciences University, interested persons can call 787-840-2575, ext. 5724 or visit www.psm.edu.

     

     

  • Instituto Nacional del Cáncer otorga $435,000 a Ponce Medical School Foundation

    Instituto Nacional del Cáncer otorga $435,000 a

    Ponce Medical School Foundation

    La subvención ayudará a fortalecer los trabajos en investigación sobre cáncer que lleva a cabo la fundación tras el paso del huracán María

    Un donativo de $435,000 por parte del Instituto Nacional del Cáncer, permitirá a Ponce Medical School Foundation, Inc., en conjunto al H. Lee Moffitt Cancer Center (MCC) de Tampa, Florida, identificar las necesidades médicas, psicológicas y las barreras para recibir acceso a servicios en pacientes de cáncer en Puerto Rico luego del huracán María. También ayudará en el estudio de la relación entre niveles altos de estrés y el impacto que pueda tener en la progresión de cáncer en esta población.
    “Estamos sumamente orgullosos del equipo de investigadores de nuestras Divisiones de Cáncer y de Comunidad. Esta subvención es de suma importancia para poder identificar esas barreras en servicios de salud que enfrentaron pacientes de cáncer luego del huracán María.

    Esta información podrá ayudar a establecer medidas de preparación y resiliencia que provean un sistema de salud más eficiente para poblaciones necesitadas, ante cualquier evento futuro. El plan propuesto es cónsono con nuestra misión de buscar soluciones a los problemas de salud más apremiantes para la comunidad hispana”, dijo la Dra. Kenira Thompson, presidenta del Ponce Medical School Foundation, Inc.

    Este proyecto establece un paso importante para mejorar la educación, la investigación y la creación de empleos en Puerto Rico. “Ponce Health Sciences University” está en una posición única para abordar los problemas de salud existentes tanto local como mundialmente, y estamos comprometidos en proveer la infraestructura necesaria para avanzar en nuevos descubrimientos en cáncer, además de mejorar las oportunidades de salud y educación aquí en Puerto Rico y en la Florida”, dijo David Lenihan, presidente de Ponce Health Sciences University.
    Esta nueva subvención se une al nutrido grupo de investigaciones que surgen como parte de la alianza colaborativa entre Ponce Health Sciences University y MCC por más de 11 años. Los investigadores principales de esta nueva subvención son: Dra. Eida Castro (PHSU) y la Dra. Heather Jim (MCC). La doctora Castro es la investigadora principal de este proyecto. El equipo de investigación está compuesto por el Dr. Guillermo Armaiz (PHSU), Dra. Mary Rodríguez (PHSU) y la Dra. Idhaliz Flores (PHSU).

    Ponce Medical School Foundation, Inc. es una entidad sin fines de lucro (501 c.3) que provee la infraestructura de investigación a Ponce Health Sciences University. Su misión es llevar a cabo investigaciones de alto calibre que ayuden a disminuir las disparidades de salud que enfrentan los pacientes puertorriqueños.

    Ponce Health Sciences University, antes Escuela de Medicina de Ponce, es una institución universitaria con un enfoque en las disciplinas de Medicina, Psicología Clínica, Ciencias Biomédicas, Salud Pública y Enfermería. Desde 1977 ha desarrollado profesionales altamente capacitados en en el campo de la salud. Ahora cuenta con un centro educativo en Santurce que ofrece una Maestría en Ciencias Médicas y un Doctorado en Psicología Clínica.